Case Report #41: Ketamine Bladder Pain by Dr Matthew Cole and Dr Sunil Dasari

Published: 30/07/2024

Assessment

What is the differential diagnosis?

  • Ketamine induced cystitis (KIC)
  • Interstitial cystitis
  • Painful bladder syndrome
  • Overactive bladder
  • Recurrent UTI (Urinary tract infections)
  • Chronic pelvic pain syndrome
  • Chronic urethral syndrome
  • Prostatitis in men
  • Endometriosis in female

 

Ketamine induced cystitis (KIC) patients often present with lower urinary tract symptoms (LUTS).  These include haematuria, hydronephrosis, suprapubic pain, dysuria, sterile pyuria, nocturia and increased eosinophil presence.  Diagnostic tools include urinalysis, cystoscopy, ultrasound and imaging tests such as X-rays and CT urograms.

 

How is Ketamine induced cystitis distinguished from other inflammatory bladder diseases?

The involvement of ureter and thickened bladder wall is a feature of KIC that distinguishes its pathophysiology from other inflammatory bladder diseases such as interstitial cystitis (IC) and painful bladder syndrome ¹.